Evaluation of Telomere Length in Women with Polycystic Ovary Syndrome and its Association to Metabolic Syndrome, Obesity and Hiperandrogenism.

MILLÁN ANDREA LILIANA; IGLESIAS MOLLI ANDREA ELENA; ABRUZZESSE GISSELLE; CERRONE GLORIA EDITH; MOTTA ALICIA; VELAZQUEZ MARIELA EDITH; GRAFFIGNA MABEL NORA

Mendoza

Simposio; II International Symposium On Translational Medicine XIII Annual Meeting of Investigation at The Faculty of Medical Sciences.; 2019

Faculty of Medical Sciences; Faculty of Exact and Natural Sciences at Universidad Nacional de Cuyo; Faculty of Pharmacology and Biochemistry at Universidad de Buenos Aires and the Faculty of Medicine at Albert-Ludwigs-Universität Freiburg, Germany.

Introduction and Objectives:Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among young women. Telomere shortening is involved in the replicative capacity of a cell, considered as a marker of cellular aging. We aimed to determine the absolute Telomere Length (aTL) in women with PCOS and study their association with Metabolic Syndrome (MetS) and the presence of obesity and Hyperandrogenism (HA), in comparison with healthy controls. Methods:We studied 130 women with POCS and 86 age-matched healthy control women. Biochemical, clinical, anthropometric hormonal parameters have been measured. The aTL was performed on genomic DNA from peripheral blood leukocytes by Real Time PCR absolute quantitative method. Statistical analysis was carried out by one-way ANOVA and linear regression. Results: The whole sample (PCOS and Controls) showed an inverse relationship between aTL and age (p=0.004). Mean aTL was significantly higher in metabolically healthy PCOS patients compared to healthy control (p