INIGEM   23989
INSTITUTO DE INMUNOLOGIA, GENETICA Y METABOLISMO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
LOW TLR9 EXPRESSION IN ADAPTIVE CELLS PROTECTS AGAINST PROGRESSION OF NONALCOHOLIC FATTY LIVER DISEASES
Autor/es:
ALEJANDRA C. CHERÑAVSKY; LUIS COLOMBATO; CECILIA C. GARCIA; DANIEL PONCINO; LUIS A. BILLORDO; DANIEL GARCÍA; JAVIER BENAVIDES; NADIA S. ALEGRE
Lugar:
Buenos Aires
Reunión:
Congreso; Reunión Conjunta de Sociedades de Biociencias; 2017
Institución organizadora:
SAA,SAB,SAIC;SAIB;SAI;SAFE;SAH;SAP;SAFIS.
Resumen:
Introduction: T cells play a key role on the progress of nonalcoholic fatty liver disease (NAFLD). Signaling through Toll-likereceptors (TLRs)co-stimulates the activaation, differentiation and generation of memory T cells.No study correlates clinical facts inNAFLD with TLR expression and function of adaptive cells.Conclusions: A global decrease of TLR9 expression in adaptive cells is linked todistinctive metabolic changes associated with NAFLD. In addition, the relation describedbetween T cell activation and TLR9 expression evidences its protective role against anincreased differentiation of CD8+ cells at early stages of NAFLD progression