Coenzyme Q10 levels in maternal plasma and cord blood in intrahepatic cholestasis of pregnancy.

BEATRIZ PERAZZI ; HILDA RUDA VEGA; PAULA SAMASSA; LILIANA G. BIANCIOTTI; MARIA BEATRIZ DI CARLO; MANUELA MARTINEFSKI; VALERIA TRIPODI; SILVIA LUCANGIOLI; SILVIA COCUCCI

Buenos Aires

Congreso; Reunión Conjunta de Sociedades Biomédicas.; 2017

Sociedad Argentina de Investigación Clínica

Abstract: Intrahepatic cholestasis of pregnancy (ICP) is a high-riskmedical condition due to the serious consequences it may have onthe fetus. ICP is characterized by bile acid accumulation in maternalserum which leads to an imbalance between reactive oxygen speciesproduction and antioxidant defenses thus enhancing an oxidativeenvironment for the fetus. In previous studies we reported thatwomen with ICP have decreased plasma coenzyme Q10 (CoQ10)levels. CoQ10 is a redox substance integrated into the mitochondrialrespiratory chain which acts as an electron carrier to generatecellular energy. Further, it is recognized as the primary regeneratingantioxidant playing an intrinsic role against oxidative insult. In thepresent study, we measured CoQ10 and bile acids levels in maternaland umbilical cord blood in normal pregnancy and ICP (n= 23and n=13, respectively). Total bile acids (TBA) were significantlyhigher in maternal and umbilical cord blood from ICP (p