Serum immunological mediators are associated with anemia in patients with celiac disease. A prospective follow-up assessment

E. MAURIÑO; SZRETTER M; TEMPRANO MP; SMECUOL E; HORACIO VAZQUEZ; BAI JC; A CHERÑAVSKY; RODRIQUEZ D; GONZÁLEZ A; MAZZURE R; SUEZ M; SUGAI E; COSTA A; NIVELONI SI; ML MORENO

Washington

Congreso; Digestive Disease Week; 2018

American Soc of Gastroenterology

Abstract Body: Background: Celiac disease (CD), a common autoimmune disorder as consequence of gluten intake,is often associated to chronic anemia, which is considered as the most frequent extraintestinal manifestation. Anemiahas been thought to be produced as consequence of iron deficiency secondary to malabsorption. The role ofimmunological mediators (IM) in the development of anemia has been scantly explored.Objective: Our aim was to explore the relationship between the presence of anemia in CD patients and a series of IMboth assessed at diagnosis and after one-year on a gluten-free diet (GFD).Methods: We prospectively collected blood samples from 16 consecutive CD patients, both at the time of diagnosis ofCD and after one year on a GFD. We used the Bio-Plex Pro? Human Cytokine 27-plex Assay (Bio-Rad Laboratories)to measure serum IM levels. We also evaluated the relationship among anemia with histological parameters (Marshclassification and intraepithelial lymphocyte -IEL- count) and the CD specific serology. We used the correctedWilcoxon test for paired samples to evaluate IM levels across the treatment. Anemia was defined as hemoglobin (Hb)concentrations