Dietary intake and biochemical parameters related to bone health in women over 65 years old in the Buenos Aires city, Argentina.

OLIVERI B; SOMOZA J; BRITO G; LOPEZ BEATRIZ LAURA

Congreso; INTERNATIONAL CONGRES NUTRITION; 2017

144/1938 DIETARY INTAKE AND BIOCHEMICAL PARAMETERS RELATED TO BONE HEALTH IN WOMEN OVER 65 YEARS OLD IN THE BUENOS AIRES CITY, ARGENTINA (1)Brito, Graciela Mabel; (2)Somoza, Julia; (3)Oliveri, Beatriz; (4)López, Laura Beatriz. (1)BSc. Nutritionist. Escuela de Nutrición. Universidad de Buenos Aires. Argentina. Laboratorio de Enfermedades Metabólicas Óseas. Instituto de Inmunología Genética y Metabolismo (INIGEM) CONICET-UBA. Argentina.; (2)Laboratory Technician. Laboratorio de Enfermedades Metabólicas Óseas. Instituto de Inmunología Genética y Metabolismo (INIGEM) CONICET-UBA. Argentina.; (3)PhD. Medicine. Laboratorio de Enfermedades Metabólicas Óseas. Instituto de Inmunología Genética y Metabolismo (INIGEM) CONICET-UBA. Argentina.; (4)PhD. Nutritionist. Escuela de Nutrición. Universidad de Buenos Aires. Argentina. Background and objectives: Both nutritional status and bone health influence elderly?s health and quality of life. The aim of this study was to evaluate: the relationship between the nutritional status of vitamin D (VD) and biochemical markers of bone turnover; the relationship between the intake of Calcium (Ca), protein, VD and vitamin K (VK) and bone formation and resorption markers; the relationship between total osteocalcin (OC) and undercarboxylated osteocalcin (ucOC) to VK intake and bone remodeling parameters. Methods: 102 healthy women were evaluated, with age: (X±SD) 71±5 years, BMI 28.7±3.8 kg/m2. A validated food frequency questionnaire was used to asses? dietary intake. Serum 25 hydroxyvitamin D (25OHD), crosslaps (sCTX), bone alkaline phosphatase (BAP), calcium (sCas), phosphorus (sP), OC y unOC were determined in blood samples and calcium/creatinine ratio (uCa/uCr) in 24-hour urine samples. Data were analyzed applying descriptive statistics, Kolmogorov-Smirnov, Mann-Whitney and Pearson or Spearman correlation. Linear regression models were used to analyze the relationship between numerical variables. Results: Calcium, VK and VD intakes were lower than the recommended doses 79%, 33.7% and 100% of population respectively. Median protein intake was 1.03 g/kg body weight/d, with 100% reporting intakes higher than the recommended. Vitamin D insufficiency affected 32.7% of women and deficiency 55.9%, higher levels of sCTX were observed in those women with lower 25OHD levels. Conclusions: The intake pattern was high in protein, and deficient in calcium, VD and VK. Poor vitamin D status affected 93% of women, with an increase in bone remodeling observed in severe deficiency. The ucOC was related to VK intake, so it could be considered an adequate indicator of its nutritional status, while OC and its relation to sCTX would reflect the increase in bone remodeling Keywords: Elderly, bone health, intake, nutritional status