INIGEM   23989
INSTITUTO DE INMUNOLOGIA, GENETICA Y METABOLISMO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Promising therapeutic effect of coenzyme Q10 in ethinyl estradiol-induced cholestasis.
Autor/es:
MARTINEFSKI, MANUELA; SILVIA LUCANGIOLI; FABIAN BUONTEMPO; MYRIAN R. RODRIGUEZ; VALERIA TRIPODI
Lugar:
Mar del Plata
Reunión:
Congreso; LXI REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INVESTIGACIÓN CLÍNICA (SAIC) LXIV REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INMUNOLOGÍA (SAI) XLVIII REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE FARMACOLOGÍA EXPERIMENTAL (SAFE) VII REUNIÓN ANUAL DE LA SOCIEDAD; 2016
Institución organizadora:
SAIC
Resumen:
ntrahepatic cholestasis of pregnancy C is a high ris liverdisease given the eventual deleterious consequences that mayoccur in the fetous. C is characterized by the accumulation ofbile acids, particularly hydrophobic bile acids such as litocholic acidLCA, hich induces oxidative stress and apoptosis. e previouslyreported that omen ith C sho decreased coenzyme Co and enhanced bile acids in plasma. These findingsere also observed in ethinyl estradiol EEinduced cholestasisin rats. The aim of this or as to evaluate the effect of Cosupplementation in EE-induced cholestasis in rats. Cholestasisas induced in Spraguealey rats by a daily intraperitonealinjection of mg/g EE for days EE. A group of these ratsalso received daily oral mg/g Co supplementation for days EECo. Another group of rats received only Cosupplementation for the same period of time Co. Serum,bile acids total and LCA, coenzyme Co and Co, aspartateaminotransferase, alanine aminotransferase, and alalinephosphatase ere assessed. ile flo as also measured. odifferences ere observed beteen Co and control groupsexcept for an increase in plasma Co p.. Hoever,Co supplementation in cholestatic rats EECo increasedboth Co and Co plasma levels p., and enhanced bileflop. as compared ith EE. Furthermore, it also decreasedserum alaline phosphatase and bile acids, particularly LCA levelsas compared ith EE p.. resent findings sho that Coadministration improved cholestasis and further suggest thatCo supplementation may be a potential therapeutic strategyin estrogen-induced cholestasis in humans as ICP.