Low TLR9 expression in CD4 + and CD8 + human peripheral blood cells might play a role in NAFLD

LUIS A. BILLORDO; FRÍAS S; ALEGRE NS; BENAVIDEZ J; AMEIGEIRAS B; GARCÍA CC; COLOMBATO L; ALEJANDRA CLAUDIA CHERÑAVSKY

Mar del Plata

Encuentro; LXIV Reunión Anual de la Sociedad Argentina de Inmunología; 2016

Sociedad Argentina de Inmunología

Liver exposure to intestinal-derived bacterial products promotes a pro-inflammatory milieu that induces innate immunity and contributes to thepathogenesis of nonalcoholic fatty liver disease (NAFLD) via pattern-recognition receptors such as Toll-like receptors (TLRs). TLRs are expressed in T cellsand co-stimulate its activation. Particularly, TLR9 recognize bacterial DNA and is involved in Kupffer cell activation leading to nonalcoholicsteatohepatitis. Aims: To evaluate TLR9 expression in peripheral blood (PB) and liver infiltrating T cells from NAFLD patients and healthy donors, and Itsco-stimulatory role in circulating T cells.