INIGEM   23989
INSTITUTO DE INMUNOLOGIA, GENETICA Y METABOLISMO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Polycomb Repressor Complex 2 in Metabolic Homeostasis.
Autor/es:
PÉREZ PÁEZ I, POSPISILIK JÁ, TEPERIO R, CARRERAS MC.
Lugar:
Buenos Aires
Reunión:
Congreso; II International Congress in Translational Medicine (IMBS); 2015
Institución organizadora:
Universidad de Buenos Aires- Albert-Ludwigs University of Freiburg
Resumen:
Obesity is a chronic, multifactorial, progressive and systemic disease, defined as abnormal or excessive fat accumulation that results from an imbalance of food intake, basal metabolism, and energy expenditure. At an individual level, multiple endogenous or environmental causes could lead to obesity. Until now more than 100 genes have been identified that influence body weight. Recently it was described Polycomb-Trithorax system (PcG-Trx) as one of the most enriched obesity-altering pathway. Different studies have suggested the importance of Eed in recruiting PRC2 to the chromatin and propagating H3K27me3 mark for the maintenance of repressive chromatin state in a cell. Besides its prominent role in development, previous data suggest, that the PcG/Trx system could have a role in metabolic function. Nevertheless until now there is little systematic knowledge about PcG/TrxG function in adipose tissue in vivo. Here, we used a conditional deletion strategy to generate adipose tissue specific PRC2 knockout (Ap2-EedKO) and test its role in adipose tissue differentiation and function.Ap2-EedKO mice show signs of brown adipose tissue differentiation upon high fat diet accompanied by pronounced insulin resistance and glucose intolerance. Both phenotypes are not evident on normal feeding conditions. Thus, our findings suggest that Eed (and therefore PRC2) is essential for adipose tissue terminal differentiation and function in metabolic control.