Vitamin D Levels in HIV Infected Adults and its Relation with Immunologic and Virologic Status. Exploratory Study

DRA. SILVINA MASTAGLIA; DRA NATALIA BELLO; DRA VANESA FRIDMAN; DR DANIEL STECHER; DRA BEATRIZ OLIVERI

Baltimore

Congreso; Meeting America Society for Bone and Mineral Research; 2013

ASBMR

J Bone Miner Res 28 suppl 1, 2013Vitamin D has strong immunomodulting properties. The nuclear vitamin D receptor is expressed in various immune cell lines which locally convert vitamin D to its active form 1,25-dihydroxyvitamin D (1,25[OH]2 D). Under infection condition 1,25[OH]2 D stimulate the production in monocytes and macrophages the antimicrobial peptide, cathelicidin. In vitro studies demonstrate cathelicidin¡¯s ability to inhibit HIV replication in CD4+ T cell and macrophages. Aim: evaluated the relationship between 25-hidroxyvitamin D (25OHD), CD4 and HIV viral load. Fifty six clinical records from patients with diagnostic HIV/AIDS attending to the Division of Infectology, Department of Internal Medicine, Clinical Hospital, Buenos Aires University. The data of clinical record as predictors of low vitamin D metabolite were the following: age, gender, ethnicity, duration of HIV infection, hepatic and renal diseases, diagnostic of osteopenia or osteoporosis, vitamin D supplementation and season in that 25OHD was measured. The biochemical parameters were: 25OHD [RIA-DIASORIN], CD4 cell count (absolute number and percentage) and HIV viral load. We considered for this study 25OHD levels sufficient that ¡Ý30ng/ml, insufficient: 21-29ng/ml, inadequate ¡Ü20ng/ml and deficient ¡Ü10ng/ml. Results: In the table 1 showed characteristics of the 56 patients according to 25OHD levels. We observed that 76% of the patients with HIV/AIDS showed 25OHD levels below 30ng/ml (insufficient 28%; inadequate: 30% and deficient: 20%). Our results are consistent with others HIV cohorts recent report1-3. A weak negative lineal correlation was observed between 25OHD levels deficient and HIV load, log10 (r=-0.591; p<0.05) but there are no correlations between 25OHD and CD4 (absolute number/%). Conclusion: Vitamin D deficiency was common in this HIV population, as seen in other HIV cohorts. Vitamin D deficit may affect the immune responder to HIV viral load. Future studies are required to understand the vitamin D metabolism in the HIV/AIDS infection