Leukocyte telomere length is associated with iron overload in male adults with hereditary hemochromatosis

MILLAN, ANDREA; BOTTA, ELIANA; REY, JORGE; MERONO, TOMAS; LOZANO CHIAPPE, EZEQUIEL; FERRARO, FLORENCIA; CASTRO, MARCELO; DARUICH, JORGE; CERRONE, GLORIA; MARTÍN, MAXIMILINO; TETZLAFF, WALTER F.; BOERO, LAURA; FRECHTEL, GUSTAVO; BRITES, FERNANDO; MILLAN, ANDREA; BOTTA, ELIANA; REY, JORGE; MERONO, TOMAS; LOZANO CHIAPPE, EZEQUIEL; FERRARO, FLORENCIA; CASTRO, MARCELO; DARUICH, JORGE; CERRONE, GLORIA; MARTÍN, MAXIMILINO; TETZLAFF, WALTER F.; BOERO, LAURA; FRECHTEL, GUSTAVO; BRITES, FERNANDO

BIOSCIENCE REPORTS

PORTLAND PRESS LTD

Lugar: Londres; Año: 2020 vol. 40

0144-8463

Background: Hereditary hemochromatosis (HH) is a primary iron overload (IO) condition. Absolute telomere length (ATL) is a marker of cellular aging and DNA damage associated with chronic diseases and mortality. Aim: To evaluate the relationship between ATL and IO in patients with HH. Methods: Cross-sectional study including 25 patients with HH: 8 with IO and 17 without IO (ferritin < 300 ng/ml) and 25 healthy controls. Inclusion criteria were: Age > 18 years, male sex and HH diagnosis. Patients with diabetes or other endocrine and autoimmune diseases were excluded. ATL was measured by real-time PCR. Results: HH patients with IO were older (P