INIGEM   23989
INSTITUTO DE INMUNOLOGIA, GENETICA Y METABOLISMO
Unidad Ejecutora - UE
artículos
Título:
LOCAL EFFECTS OF LOW DOSES OF PTH 1-34 ON EXPERIMENTAL PERIODONTITIS
Autor/es:
DAVISON, MARIO R.; BONANNO MARINA SOLEDAD; BIDEVICH, NL; ZENI SUSANA NOEMÍ; PRELIASCO, MARIANA
Revista:
MEDICINA (BUENOS AIRES)
Editorial:
MEDICINA (BUENOS AIRES)
Referencias:
Año: 2020 vol. 80 p. 65 - 65
ISSN:
0025-7680
Resumen:
Periodontitis is a highly prevalent, chronic disease that induces a progressive bone resorption. Intermittent PTH administration has anabolic and anti-inflammatory effects, two properties necessary to achieve bone recovery. Periodontal disease can be experimentally induced in rats in few days, via cotton ligatures placement in the gingival sulcus around the molar teeth, that increases biofilm accumulation and disruption of the gingival epithelium, enhancing osteoclastogenesis and bone loss. We investigated whether intermittent administration of a low dose of PTH 1-34 in rats would block the alveolar bone loss observed when the ligature model of periodontitis was used. Periodontitis was induced in 16 female Wistar rats (221±15g) under light anesthesia. Ligature was replaced every 4 days. Rats were randomly divided in two groups and subcutaneously injected every 48 hs for 18 ds. with: G1 saline solution and G2 1.2ug PTH1-34. Eight rats were left unligated as healthy control. After killed hemimandibles were extracted and fixed in formalin buffer for histologic analysis of tibia subchondral bone volume (BV/TV%), alveolar bone BV/TV% and periodontal space height (PSH). Results: tibia BV/TV%: C 38.77±2.59; G1 38.29±3.9 and G2 37.75±1.45; alveolar bone BV/TV% C 50.3±3.6c; G1 35.6±4.3a and G2 42.0±1.4b; PSH (mm): C: 0.196±0.057a; G1 0.809±0.115b and G2: 0.706±0.065c. Different letters show a p