Hipopara-Red, Real Life Experience in 322 Patients with Hypoparathyroidism

OLIVERI, BEATRIZ; KALLSBRUM, SILVIA; DIAZ, ADRIANA; ARCE LANGE, MARÍA AUXILIADORA; GALICH, ANA MARÍA; ZANCHETTA, MARÍA BELÉN; GIACOIA, EVANGELINA; SALERNI, HELENA; PEREZ, BETIANA; TORMO, SILVINA; ROBBIANI, DAMIÁN; FRIGERI, ADRIANA; LUCAS, SABRINA; PIERONI, LUISINA; KITAIGRODSKY, ARIELA

Journal of the Endocrine Society

OXFOR ACADEMIC

Año: 2020

ContextHypoparathyroidism is a rare disease and as such, its natural history, long term complications and correct clinical management remain unclear.ObjectiveTo describe the natural history and clinical characteristics of the disease.Design and settingTopresent a retrospective observational analysis from seven specialized centers in Buenos Aires, Argentina.Patientschronic hypoparathyroid patients followed up between 1985 and December 2018.Main Outcome Measuresdata on demographics, etiology, clinical complications, biochemical parameters, DXA values and treatment doses were collected.Results322 subjects with chronic hypoparathyroidism were included, 85.7 % were female. Mean age was 55.2 ± 16.8 years and mean age at diagnosis was 43.8 ± 16.8. Prevalence of surgical hypoparathyroidism was 90.7 %, most common causes being thyroid carcinoma and benign thyroid disease. A history of hypocalcemia requiring hospitalization was present in 25.7 % and 4.3 % had a history of seizures. Overall, 40.9 % had reported at least one neuromuscular symptom. Renal insufficiency was present in 22.4 % and was significantly associated with age (p