INIGEM   23989
INSTITUTO DE INMUNOLOGIA, GENETICA Y METABOLISMO
Unidad Ejecutora - UE
artículos
Título:
In vivo drug resistance mutations dynamics from early to chronic stage of infection in antiretroviral therapy-naïve HIV-infected men who have sex with men
Autor/es:
CULASSO, ANDRES; SUED, OMAR; DELPINO, MARÍA VICTORIA ; CULASSO, ANDRES; SUED, OMAR; DELPINO, MARÍA VICTORIA ; C. CEVALLOS; OJEDA, DIEGO; AVILA, MARÍA MERCEDES; C. CEVALLOS; OJEDA, DIEGO; AVILA, MARÍA MERCEDES; URQUIZA, JAVIER; FIGUEROA, MARIA; QUARLERI, JORGE ; URQUIZA, JAVIER; FIGUEROA, MARIA; QUARLERI, JORGE
Revista:
ARCHIVES OF VIROLOGY
Editorial:
SPRINGER WIEN
Referencias:
Lugar: Viena; Año: 2020
ISSN:
0304-8608
Resumen:
Human immunodeficiency virus type 1 (HIV) primary drug resistance mutations (DRMs) influence the long-term therapeutic effects of antiretroviral treatment (ART). Drug-resistance genotyping based on polymerase gene sequences obtained by next-generation sequencing (NGS) was performed using samples from 10 ART-naïve HIV-infected men who have sex with men (MSM; P1-P10) from the acute/early to chronic stage of infection. Three of the 10 subjects exhibited the presence of major (abundance, ≥ 20%) viral populations carrying DRM at early/acute stage that later, at the chronic stage, dropped drastically (V106M) or remained highly abundant (E138A). Four individuals exhibited additional DRMs (M46I/L; I47A; I54M, L100V) as HIV minority populations (abundance, 2?20%) that emerged during the chronic stage but ephemerally.