Comparative body mass index effect on total and undercarboxilated osteocalcina between normoglucemic premenopausal women and men

WATSON, DANA; ZENI, SUSANA NOEMÍ; BONANNO, MARINA SOLEDAD; ZAGO, LILIANA; BRITO, GRACIELA; INFANTINO, CARLOS ALFREDO GONZALEZ

Bone Reports

Elsevier Inc

Año: 2020 vol. 13

2352-1872

We found that body mass index (BMI) through leptin affected osteocalcin (OCN), which in turn influences insulin and glucose homeostasis in men. Now we evaluated such effect in 35 premenopausal women (PMW) comparing the results obtained in these 45 men. All subjects were non-diabetic having normal glucose and HbA1c and were divided according to BMI index in overweight (OW) or type I, II, III obesity (OB) degree. Glucose, HbA1c were measured by standard methods; undercarboxilated OCN (ucOCN) (ng/mL), total OCN (ng/mL), leptin (ng/mL), insulin (uUI/L) and CTX (ng/L) by ELISA, and 25hydroxyvitaminD (25OHD) (ng/mL) by a competitive protein-binding method. Results (mean±SD): In both genders, ucOCN increased and OCN decreased with BMI increase (P