INIGEM   23989
INSTITUTO DE INMUNOLOGIA, GENETICA Y METABOLISMO
Unidad Ejecutora - UE
artículos
Título:
Limited expression of TLR9 on T cells and its functional consequences in patients with nonalcoholic fatty liver disease
Autor/es:
GARCIA, CECILIA CLAUDIA; PONCINO, DANIEL; CHERÑAVSKY, ALEJANDRA CLAUDIA; BILLORDO, LUIS ARIEL; BENAVIDES, JAVIER; ALEGRE, NADIA SOLEDAD; AMEIGEIRAS, BEATRIZ; COLOMBATO, LUIS
Revista:
Clinical and Molecular Hepatology
Editorial:
The Korean Association for the Study of the Liver
Referencias:
Lugar: Seúl; Año: 2019 p. 1 - 11
ISSN:
2287-2728
Resumen:
We demonstrated a limited expression of Toll-like receptor 9 (TLR9) and interferon gamma (IFN-γ) production by T cells in patients with simple steatosis (SS). The limited expression of TLR9 on T cells was directly associated with lower liver necroinflammatory activity and fibrosis, and lower antrophometric and biochemical alterations of nonalcoholic fatty liver disease. Besides, co-stimulation of T cell activation via TLR9 induced a limited number of IFN-γ-producing CD8+ T cells in SS patients. Accordingly, these patients showed a low frequency of circulating type 1 CD8+ cells whereas additional pro-inflammatory signals may be responsible for the higher frequency observed at baseline in the context of steatohepatitis.