INIGEM   23989
INSTITUTO DE INMUNOLOGIA, GENETICA Y METABOLISMO
Unidad Ejecutora - UE
artículos
Título:
Inhibition of antigen presentation by Brucella: many more than many ways
Autor/es:
BARRIONUEVO P.; GIAMBARTOLOMEI GH
Revista:
MICROBES AND INFECTION
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2019
ISSN:
1286-4579
Resumen:
Brucellainfection activates the immune system and favorsthe differentiation of CD4+ and CD8+ T cells.To persist during a long time inside macrophages evading immune surveillance ofthese T cells the pathogen must exploit different evasion strategies. We reviewthe mechanisms whereby Brucella,through TLR signaling, inhibits MHC class I and II antigen presentation,allowing infected macrophages to become effective niches for Brucella survival.