Effect of adding a galacto-oligosaccharides/ fructo-oligosaccharides (GOS/FOS®) mixture to a normal and low calcium diet, on calcium absorption and bone health in ovariectomy-induced osteopenic rats

BRYK GABRIEL; M.E. RIO,; ZENI CORONEL M; DE PORTELA M. L; SEIJO M; BONNANO M; ZENI SN

CALCIFIED TISSUE INTERNATIONAL

SPRINGER

Lugar: Berlin; Año: 2018 vol. 104 p. 301 - 312

0171-967X

Abstract Scope: Menopause is associated with bone loss. Prebiotics increase Ca, phosphorus (P) and Mg absorption, improving bone health. These increases would supply an extra-amount of minerals, decreasing bone resorption and possibly reversing ovariectomy-induced bone loss. The present experimental study sought to evaluate the effect of adding a prebiotic GOS/FOS® mixture to a normal or a low Ca diet on Ca, Pi and Mg absorption, in osteopenic rats.Methods and results: Four groups of n=8 rats each were OVX, and 8 rats were SHAM operated. All rats were fed acommercial diet for 45 days. They were then fed one of the following diet for 45 days: C-0.5%: SHAM fed AIN 93 M containing 0.5%Ca; O-0.5% and O-0.3%: OVX rats fed AIN 93 M, containing 0.5% or 0.3%Ca, respectively; GF- 0.5% and GF-0.3%: OVX rats fed AIN 93 M, containing 0.5% or 0.3%Ca + 2.5% GOS/FOS®, respectively. Results: At the end of the experimental time point, Ca, P, and Mg Abs% was significantly higher in GF-0.5% and GF-0.3% as compared to the remaining groups (p