INIGEM   23989
INSTITUTO DE INMUNOLOGIA, GENETICA Y METABOLISMO
Unidad Ejecutora - UE
artículos
Título:
Exploratory, Randomized, Double-blind, Placebo-controlled Study on the Effects of Bifidobacterium infantis Natren Life Start Strain Super Strain in Active Celiac Disease
Autor/es:
SMECUOL EDGARDO; HWANG HJ; SUGAI E; CORSO L; CHERÑAVSKY AC; BELLAVITE FP; GONZáLEZ A; VODáNOVICH F; MORENO ML; VáZQUEZ H; NIVELONI S; MAZURE R; MEDDINGS J; MAURIñO E; BAI JC
Revista:
JOURNAL OF CLINICAL GASTROENTEROLOGY
Editorial:
LIPPINCOTT WILLIAMS & WILKINS
Referencias:
Lugar: Philadelphia; Año: 2013 vol. 47 p. 139 - 147
ISSN:
0192-0790
Resumen:
Background/Aims: The aim of this exploratory study was to assess the effect of Bifidobacterium infantis in patients having serological evidences of untreated celiac disease (CD). Methods: Twenty-two adult patients with two concomitantly positives CD-specific tests were enrolled in the study. Patients were randomized to receive two capsules before meals for 3 weeks of either Bifidobacterium infantis NLS super strain (Natren Duo®) (2 x 109 colony-forming units per capsule) (n=12) or rice flour, dehydrated potato powder, cellulose powder, and hydroxypropyl- methylcellulose as placebo (n=10). Patients consumed at least 12 g of gluten/day during the study period. Biopsy at the end of the trial confirmed CD in all cases. Results: In contrast to patients in placebo, those randomized to B. infantis experienced a significant improvement in syndromes of the gastrointestinal syndrome rate scale scores (p=0.0035 for indigestion, p=0.0483 for constipation and p=0.0586 for reflux). Final/baseline IgA tTG and IgA DGP antibody concentration ratios decreased in the B. infantis arm (p=0.055 for IgA tTG and p=0.181 for IgA DGP) but not in placebo. Final serum MIP-1â increased significantly (p<0.04) only in patients receiving B. infantis. The final/baseline IL-12p70 ratio in supernatant of peripheral blood mononuclear cells culture was increased in the placebo arm (p<0.02) but not in the probiotic. No significant changes were found in intestinal permeability. Conclusion: This is the first study to explore the effect of B. infantis in untreated CD. The probiotic improved perception of symptoms. However, we were not able to detect significant changes in the immunologic profile and in intestinal permeability. The administration of B. infantis was safe. Keywords: Celiac disease, probiotics, Bifidobacteria infantis, gluten-free diet.