INSTITUTO DE INVESTIGACIONES EN MICROBIOLOGIA Y PARASITOLOGIA MEDICA
Unidad Ejecutora - UE
capítulos de libros
Molecular ecology of class 1 integrons in Patagonia as model study for understanding the rise of antibiotic resistance isolates around the world
MARÍA PAULA QUIROGA; CENTRÓN D.; CASTRO GA; ÁLVAREZ VE; CASSINI MH
Biology and biotechnology of patagonian microorganisms.
Springer International Publishing
Año: 2016; p. 11 - 125
The discovery of antibiotics wasone of the greatest scientific achievements of the 20th century. Unfortunately, their effectiveness and easy access led tooveruse. As a result of that, over the last 80 years, there has been a remarkableevolution of antibiotic resistant strains of bacteria. This has ended in theappearance of pathogens with resistance to almost all families of antimicrobialagents (Davies and Davies, 2010; Arduino et al., 2012). Nowadays,this progressive increase of multidrug resistance in allgeographical regions is considered a main globalthreat that has beenidentified as a public health priority according toseveral organizations such as the US Centers forDisease Control and Prevention (CDC), the European Centre for DiseasePrevention and Control (ECDC) and the World Health Organization (WHO) (http://www.who.int/drugresistance).The guiding force behind the increasingrates of resistance is the abuse, misuse and overuse of antimicrobial agents,used in patients, in livestock, as growth promotion in food animals, andalso released into the environment. Theemergence of resistant microorganisms, takes place either by mutations or bythe acquisition of mobile genetic elements carrying resistance genes. Theexposure to antimicrobial agents provides the necessary selective pressure forthe rise and widespread of resistant pathogens.