Antiprotozoal activity of flavonoids from Eupatorium arnottianum.

CLAVÍN MARIA; SOSA M; FRANK F; CAZORLA S.; MALCHIODI E; MUSCHIETTI L; SPINA R.; MARTINO V

Journal of Parasitic Diseases: Diagnosis and Therapy

Allied Academies

Lugar: Londres; Año: 2016 vol. 1 p. 1 - 6

Dichloromethane and ethanol extracts of Eupatorium arnottianum were evaluated for invitroleishmanicidal activity. The dichloromethane extract produced 80% and 85% of growthinhibition on both Leishmania mexicana and Leishmania amazonensis promastigotes respectively,at a concentration of 100 μg/mL. At the same concentration, the ethanol extract inhibited thegrowth of L. mexicana and L. amazonensis promastigotes in 62% and 65% respectively. Bioassayguidedfractionation of these extracts led to the isolation and identification of flavonoids nepetin,eupatilin, jaceosidin, eriodictyol and hyperoside as bioactive compounds against both species ofLeishmania with IC50 values