IMPAM   23988
INSTITUTO DE INVESTIGACIONES EN MICROBIOLOGIA Y PARASITOLOGIA MEDICA
Unidad Ejecutora - UE
artículos
Título:
Antiprotozoal activity of flavonoids from Eupatorium arnottianum.
Autor/es:
CLAV├ŹN MARIA; SOSA M; FRANK F; CAZORLA S.; MALCHIODI E; MUSCHIETTI L; SPINA R.; MARTINO V
Revista:
Journal of Parasitic Diseases: Diagnosis and Therapy
Editorial:
Allied Academies
Referencias:
Lugar: Londres; Año: 2016 vol. 1 p. 1 - 1
Resumen:
Dichloromethane and ethanol extracts of Eupatorium arnottianum were evaluated for invitroleishmanicidal activity. The dichloromethane extract produced 80% and 85% of growthinhibition on both Leishmania mexicana and Leishmania amazonensis promastigotes respectively,at a concentration of 100 μg/mL. At the same concentration, the ethanol extract inhibited thegrowth of L. mexicana and L. amazonensis promastigotes in 62% and 65% respectively. Bioassayguidedfractionation of these extracts led to the isolation and identification of flavonoids nepetin,eupatilin, jaceosidin, eriodictyol and hyperoside as bioactive compounds against both species ofLeishmania with IC50 values
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