IMPAM   23988
INSTITUTO DE INVESTIGACIONES EN MICROBIOLOGIA Y PARASITOLOGIA MEDICA
Unidad Ejecutora - UE
artículos
Título:
Antigenic and genomic characterization of human influenza A and B viruses circulating in Argentina after the introduction of influenza A(H1N1)pdm09.
Autor/es:
RUSSO MARA; PONTORIERO ANDREA; BENEDETTI ESTEFANIA; CZECH, ANDREA; AVARO MARTIN; PERIOLO NATALIA; CAMPOS A; SAVY, VILMA; BAUMEISTER, ELSA
Revista:
JOURNAL OF MEDICAL MICROBIOLOGY
Editorial:
SOC GENERAL MICROBIOLOGY
Referencias:
Lugar: London; Año: 2014 vol. 63 p. 1626 - 1637
ISSN:
0022-2615
Resumen:
This study was conducted as part of the Argentinean Influenza and other
Respiratory Viruses Surveillance Network, in the context of the Global
Influenza Surveillance carried out by the World Health Organization
(WHO). The objective was to study the activity and the antigenic and
genomic characteristics of circulating viruses for three consecutive
seasons (2010, 2011 and 2012) in order to investigate the emergence of
influenza viral variants. During the study period, influenza virus
circulation was detected from January to December. Influenza A and B,
and all current subtypes of human influenza viruses, were present each
year. Throughout the 2010 post-pandemic season, influenza A(H1N1)pdm09,
unexpectedly, almost disappeared. The haemagglutinin (HA) of the
A(H1N1)pdm09 viruses studied were segregated in a different genetic
group to those identified during the 2009 pandemic, although they were
still antigenically closely related to the vaccine strain
A/California/07/2009. Influenza A(H3N2) viruses were the predominant
strains circulating during the 2011 season, accounting for nearly 76 %
of influenza viruses identified. That year, all HA sequences of the
A(H3N2) viruses tested fell into the A/Victoria/208/2009 genetic clade,
but remained antigenically related to A/Perth/16/2009 (reference vaccine
recommended for this three-year period). A(H3N2) viruses isolated in
2012 were antigenically closely related to A/Victoria/361/2011,
recommended by the WHO as the H3 component for the 2013 Southern
Hemisphere formulation. B viruses belonging to the B/Victoria lineage
circulated in 2010. A mixed circulation of viral variants of both
B/Victoria and B/Yamagata lineages was detected in 2012, with the former
being predominant. A(H1N1)pdm09 viruses remained antigenically closely
related to the vaccine virus A/California/7/2009; A(H3N2) viruses
continually evolved into new antigenic clusters and both B lineages,
B/Victoria/2/87-like and B/Yamagata/16/88-like viruses, were observed
during the study period. The virological surveillance showed that the
majority of the circulating strains during the study period were
antigenically related to the corresponding Southern Hemisphere vaccine
strains except for the 2012 A(H3N2) viruses.