INSTITUTO DE INVESTIGACIONES EN MICROBIOLOGIA Y PARASITOLOGIA MEDICA
Unidad Ejecutora - UE
Control and resolution mechanisms of the inflammatory response
BAIZABAL-AGUIRRE V.M.; ROSALES C; LÓPEZ-MACÍAS C. ; GOMEZ MI
MEDIATORS OF INFLAMMATION
HINDAWI PUBLISHING CORPORATION
Inflammation is beneficial to the organism because it representsone of the first barriers against external and internalstimuli. It is a complex process in which a number of cellsand molecules play different roles in a coordinated and wellcontrolledmanner. However, a failure of the mechanism thatself-regulates and resolves the process may lead to chronicinflammation, and this in turn may cause degenerativediseases such as cancer, diabetes, and autoimmune and cardiovasculardiseases. Therefore, a deep knowledge about thecellular and molecular mechanisms used to resolve inflammationis mandatory to design tools and strategies to controlit. This task is not easy taking into account that differentsignaling pathways activate several molecules involved in theresolution of the inflammatory response and some of theminterfere with cellular activities unrelated to the resolutionphenomenon. In addition, many reports have shown thatseveralmolecules activate or inhibit inflammation dependingon the tissue or the physiological context. Furthermore, it hasbeen observed that inhibition of severalmolecules consideredas proinflammatory has resulted in the intensification of theinflammatory response.Having this is mind, this special issuehas gathered original and review articles that will help usto expand our knowledge on the complex process of theinflammation control and resolution. More importantly, thepapers presented in this special issue are a good referenceto recognize what type of studies is missing and the way wecould fill the gaps.