IBIMOL   23987
INSTITUTO DE BIOQUIMICA Y MEDICINA MOLECULAR PROFESOR ALBERTO BOVERIS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Cardiovascular changes produced by chronic iron overload and administration of vitamin in experimental metabolic syndrome
Autor/es:
BILBAO E; PONZO O; DONATO M; GELPI RJ; SCACHI PA; D'ANNUNZIO V; REYES TOSO C
Reunión:
Congreso; LXVI Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC); 2021
Resumen:
Chronic high-fructose-fat diet (12 weeks) induces metabolic syndrome (MS), conducting to cardiovascular disease. Systolic blood pressure (SBP) was measured in male rats (n=8-10/group) with MS, Iron overload (FE), or antioxidants -vitamins E, C and lipoic-acid- (AoV), alone or with MS (MSFE, MSAoV). After decapitation, systolic and diastolic ventricular function in basal condition and in response to isoproterenol (10-9 M) (contractile and lusitropic reserve) were assayed in isolated perfused hearts. Left ventricular developed pressure (LVDP), left ventricular end diastolic pressure (myocardial stiffness) and the relaxation half time (t1/2) were measured. Data was analyzed by Two-way ANOVA and Bonferroni posttest (p≤0.05). MSFE rose SBP vs CD in week 8. Chronic high-fructose-fat diet (12 weeks) induces metabolic syndrome (MS), conducting to cardiovascular disease. Systolic blood pressure (SBP) was measured in male rats (n=8-10/group) with MS, Iron overload (FE), or antioxidants -vitamins E, C and lipoic-acid- (AoV), alone or with MS (MSFE, MSAoV). After decapitation, systolic and diastolic ventricular function in basal condition and in response to isoproterenol (10-9 M) (contractile and lusitropic reserve) were assayed in isolated perfused hearts. Left ventricular developed pressure (LVDP), left ventricular end diastolic pressure (myocardial stiffness) and the relaxation half time (t1/2) were measured. Data was analyzed by Two-way ANOVA and Bonferroni posttest (p≤0.05). MSFE rose SBP vs CD in week 8.