Urban air pollution induces oxidative stress, inflammation and mitochondrial dysfunction in mice brain cortex and olfactory bulb

CALABRÓ, VALERIA; MAGNANI, NATALIA; VICO, TAMARA; MARTINEFSKI, MANUELA R.; GOLDSTEIN, JORGE; ALVAREZ, SILVIA; GARCÉS, MARIANA; FREIRE, AGUSTINA; BERDASCO, CLARA; BUCHHOLZ, BRUNO; GELPI, RICARDO J.; EVELSON, PABLO A.; MARCHINI, TIMOTEO; CÁCERES, LOURDES; MÉNDEZ DIODATI, NAHUEL; TRIPODI, VALERIA P.; BERRA, ALEJANDRO

Evento virtual

Conferencia; 27th Annual Conference of the Society for Redox Biology & Medicine; 2020

Society for Redox Biology and Medicine (SfRBM)

Previous reports indicate that the central nervous system (CNS) is a target of air pollution, causing tissue damage and functional alterations. Oxidative stress and neuroinflammation have been point out as possible mechanisms mediating these effects. The aim of this work was to study the chronic effects of urban air pollution on mice brain cortex (CX) and olfactory bulb (OB), focusing on oxidative and inflammatory markers, and mitochondrial function. Male 8-week-old BALB/c mice were exposed to filtered air (FA, control) or urban air (UA) inside whole-body inhalation chambers located in a highly polluted area of Buenos Aires City, for up to 4 weeks. Glutathione levels, assessed as GSH/GSSG ratio, were decreased in CX after 1 and 2 w of exposure to UA, and after 4 w in the case of the OB (26% and 60% respectively; p