IBIMOL   23987
INSTITUTO DE BIOQUIMICA Y MEDICINA MOLECULAR PROFESOR ALBERTO BOVERIS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Mitochondrial function in brain and heart of senile rats exposed to hypobaric hypoxia. Role of nitric oxide.
Autor/es:
LA PADULA, PABLO H.; JOSE MILEI; COSTA, LIDIA E.; LORES ARNAIZ, S;; KARADAYIAN AG; CZERNICZYNIEC, ANALIA
Lugar:
On line
Reunión:
Congreso; Reunión de Sociedades de Biociencias SAIC SAI SAFIS 2020,; 2020
Resumen:
In previous studies, we observed that exposure to hypobaric hypoxia (HH) can induce a cardioprotective effect that involves mitochondrial nitric oxide (NO) and differently affects cortical and hippocampal mitochondrial function. In the present work, we evaluated the impact of senility on mitochondrial function in left ventricle heart, cerebral cortex and hippocampus after an acute exposure to HH.Male Wistar rats of 22 months of age were subjected to a simulated 4,400 m altitude (58.7 kPa=440 mmHg) in a hypopressure chamber during 48h. A group of the same number of sibling rats remained as controls at sea level atmospheric pressure (101.3 kPa=760 mmHg). Oxygen consumption, mitochondrial membrane potential, hydrogen peroxide (H2O2) production and nitric oxide (NO) levels were measured in cortical and hippocampal mitochondria. In addition, cytochrome oxidase activity and NO production were evaluated in mitochondrial fractions isolated from left ventricle heart. Differences were considered significant when p