STRESSFUL LIFE EVENTS IN ALZHEIMER'S, PARKINSON'S AND ISCHEMIC STROKE DISEASES

MARSCHOFF, E; VILLAMIZAR PEREZ, S; SAPORITO MAGRIÑÁ, CHRISTIAN; OUDKERK, L; SERRA, JORGE; DOMINGUEZ, R; DE LA OSA ANGULO, L; REPETTO, MG

Buenos Aires

Congreso; ANNUAL MEETING OF BIOSCIENCE SOCIETIES 2020; 2020

LXV ANNUAL MEETING OF SOCIEDAD ARGENTINA DE INVESTIGACIÓN CLÍNICA (SAIC); LXVIII ANNUAL MEETING OF SOCIEDAD ARGENTINA DE INMUNOLOGÍA (SAI); ANNUAL MEETING OF SOCIEDAD ARGENTINA DE FISIOLOGÍA (SAFIS). Publicación: Medicina 209.(297); November 10-13, 2020

Chronic and Posttraumatic Stress Disorder are related with greater risk of developing different neuropathologies. While neither is necessary or sufficient for dementia they have been acknowledged as one of many factors intervening in pathologies such as Alzheimer?s Disease (AD), Parkinson´s Disease (PD) and Isquemic Stroke (IS). Psychological stress can trigger physiological responses, suggesting that stress could be considered as a prodromal symptom in such conditions. To examine the development of a neurological disorder AD, PD and IS after a stressful life event (SLE) in a cohort of moderate neurological patients which have experienced a psychosocial stressing event prior to initial symptoms. The interactions of Sex, Race, Age, and Economic and Cultural level with the main factor Condition or with respect to the SLE tested in a three-way ANOVA, yielded no significant values. The two-way analysis of the Condition and Stressful Event factors was conducted pooling all data. Interestingly, significant differences were found in Time-to-diagnosis and Evolution time of the disease after the different SLE in AD and PD for the comparison between Death of a familial against Work dismissal (P