Mitochondria and inflammation: tissue specific effects during endotoxemia

VANASCO VIRGINIA; EVELSON PABLO; ADAN AREAN JUAN SANTIAGO; ALVAREZ SILVIA; VICO TAMARA; MARCHINI TIMOTEO

Encuentro; SFRR-E 2021 annual meeting ?Redox Biology in the 21st Century: A New Scientific Discipline; 2021

Society for Redox Biology Reserach- Europe (SFRR-E)

Sepsis and endotoxemia are complex inflammatory syndromes that may involve bioenergetic dysfunction and lead to multi-organ failure. To unravel the importance of the bioenergetic dysfunction related to the inflammatory insult (endotoxemia) in different relevant organs (heart, brain and pancreas), Sprague-Dawley rats were i.p. injected with LPS 8mg/kg or vehicle, and after 6h were euthanized. An increase in plasma TNF-α levels was observed along with an 18-fold increase in systemic NO levels (p