IBIMOL   23987
INSTITUTO DE BIOQUIMICA Y MEDICINA MOLECULAR PROFESOR ALBERTO BOVERIS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Decreased chronic inflammation with resveratrol, alpha-tocopherol, and piperine diet supplementation in neutrophyls of patients with metabolic syndrome.
Autor/es:
MERELLI, A; BAVASSO, C; IERMOLI, R; PASTOR, R; PASTOR, I; LAZAROWSKI, A; LAIRIÓN, F; MANFREDI, Z; CONTI SAGUIER, M; REPETTO, MG
Reunión:
Congreso; Reunión Anual de Sociedades de Biociencia. SAIC, SAI, SAFIS.; 2020
Institución organizadora:
Sociedad Argentina de Investigación Clínica
Resumen:
Chronic inflammation and oxidative stress are processes associated to metabolic syndrome (MS). Currently, despite advances in the knowledge and therapeutics of MS, the mentioned processes are poorly diagnosed and treated in this disease. With the aim of evaluating the effectiveness of resveratrol supplementation on chronic inflammation associated to MS, clinical-biochemical biomarkers were analyzed in the blood of voluntary individuals participating in the study with a diagnosis of MS (n=92). The inclusion criteria were met 22 patients with an average of 68 ± 5 years (13 men, 9 women), whose diagnosis of MS was made based on the diagnostic criteria of the National Cholesterol Education Program, Adult treatment Panel III, 2002. Patients received a dietary supplement along with their usual treatment, whose formula is composed of resveratrol (50 mg), alpha-tocopherol (25 mg) and piperine (5 mg) for a period of 3 months. Piperine increases resveratrol and alpha-tocopherol absorption. Control was the patient himself in baseline conditions, avoiding interindividual variables and bioavailability of active principles. Volunteers were bled before initiation and after 3 months of treatment. Biochemical markers assessed in plasma: glucose, HDL cholesterol, triglycerides, ferritin, ultrasensitive C reactive protein (CRP); and in neutrophyls: oxygen consumption (∆O2, evaluated using a Clark type oxygen electrode) and chemiluminescence, determined with a photon counter. Results showed: triglycerides decreased by 25% (p