UNDERSTANDING THE MECHANISM OF SILVER NANOPARTICLE TOXICITY

GARCES M; MARCHINI T; GALDOPORPORA J; DESIMONE M; VERÓNICA D' ANNUNZIO; CALABRÓ V; SALGUEIRO J; MORETTON MA; ALVAREZ S; EVELSON, P; MAGNANI N; CÁCERES L; ZUBILLAGA M; PECORELLI A; VALACCHI G

FERRARA

Congreso; Society for Free Radical Research Europe Annual meeting 2019 "Redox Homeostasis: from signaling to damage"; 2019

Society for Free Radical Research

The development of silver nanoparticles (AgNP) applications increased the concern about their toxicity. As the respiratory system in one of the exposure routes, the aim of this study was to evaluate the AgNP harmful effects developed in lung. AgNP were able to cleave H2O2 leading to OH? production. In A549 cells exposed to 2.5 μg/mL AgNP a decreased mitochondrial basal and maximal respiration (p