Continuous exposure to urban air pollution induces brain oxidative stress, inflammation and impaired mitochondrial function in mice

GARCÉS MARIANA; CÁCERES L; VANASCO V; MARTINEFSKI M; GOLDSTEIN J; ALVAREZ S; CALABRÓ V; MAGNANI N; VICO T; MÉNDEZ DIODATI N; TRIPODI V; BERRA A; MARCHINI TIMOTEO; FREIRE A; BERDASCO C; BUCHHOLZ B; GELPI RJ; EVELSON P

Mar del Plata

Congreso; Reunión Anual de Biociencia 2019 - SAIC-SAFE-SAB-SAP-NANOMEDar-AACyTAL-HSC; 2019

SAIC

Increasing evidence indicates that the central nervous system (CNS) is a target of air pollution, which might lead to oxidative stress and neuroinflammation. However, the mechanisms mediating these effects have not been fully elucidated. The aim of this work was to study the effects of chronic exposure to air pollution, on mice brain cortex (CX) and olfactory bulb (OB), focusing on oxidative and inflammatory markers, and mitochondrial function. Male 8-week-old BALB/c mice were exposed to filtered air (FA, control) or urban air (UA) inside whole-body inhalation chambers located in a highly polluted area of Buenos Aires City, for up to 4 weeks. Glutathione levels, assessed as GSH/GSSG ratio, were decreased in CX after 1 and 2 w of exposure to UA, and after 4 w in the case of the OB (26% and 60% respectively; p