POTENTIAL ROLE OF INTERLEUKIN 10 ON THE EFFECTS OF FENOFIBRATE IN AN EXPERIMENTAL MODEL OF CHAGAS DISEASE.

DONATO, MARTIN; PENAS, FEDERICO NICOLÁS; MIRKIN, GERARDO A.; RADA, MARÍA JIMENA; CEVEY, ÀGATA CAROLINA; ALBA SOTO, CATALINA; PIERALISI, AZUL VICTORIA; GELPI, RJ; GOREN, NORA BEATRIZ

Mar del Plata

Congreso; LXIV Reunión Anual de la Sociedad Argentina de Investigación Clínica; 2019

Sociedad Argentina de Investigación Clínica

Chagas disease, caused by Trypanosoma cruzi (Tc) infection, is conditioned by the presence of the parasite and the development of an inflammatory response. PPARα ligands, such as fenofibrate (fen) modulate inflammation and restore ventricular function. Interleukin 10 (IL10) is produced by a variety of cells and plays an important role in the resolution of inflammatory processes. We evaluated the potential role of IL10 in the effects of fen on the modulation of the immune response and on cardiac remodeling and function, in BALB/c IL10 knockout(IL10-/-) mice infected with a non-lethal Tc strain. The ejection fraction (EF) and the shortening fraction (SF) were measured by echocardiography, which were diminished in Tc in comparison with uninfected mice (p