IBIMOL 23987
INSTITUTO DE BIOQUIMICA Y MEDICINA MOLECULAR PROFESOR ALBERTO BOVERIS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
The blockade of low affinity neurotensin receptor alters mitochondrial bioenergetics and the triade NMDA receptor, PSD-95 and nNOS proteins
Autor/es:
SILVIA LORES ARNAIZ; JENNIFER MIRANDA; ANALIA G. KARADAYIAN; GEORGINA RODRÍGUEZ DE LORES ARNAIZ; ALICIA ANGELA GUTNISKY; SILVIA LORES ARNAIZ; JENNIFER MIRANDA; ANALIA G. KARADAYIAN; GEORGINA RODRÍGUEZ DE LORES ARNAIZ; ALICIA ANGELA GUTNISKY
Lugar:
Villa Carlos Paz, Córdoba
Reunión:
Congreso; XXXIV Reunión Anual SAN 2019; 2019
Institución organizadora:
Sociedad Argentina de Investigación en Neurociencias
Resumen:
In previous work we have shown the impairment of nitric oxide (NO) production and mitochondrial alterations after the blockade of low affinity neurotensin receptor (NTS2) by levocabastine. A functional interaction between neuronal nitric oxide synthase (nNOS) and NMDA receptor through assembly with PSD-95 protein has been described. Male Wistar rats were i.p. injected with levocabastine (50 μg/kg) or saline and sacrificed 18 hours later. Brain cortex crude mitochondrial fractions and synaptosomal membranes were isolated by differential and sucrose gradient centrifugation, respectively. Levocabastine administration decreased 31% and 34% state 3 respiratory rates assayed with malate-glutamate and succinate, respectively, and 21% the mitochondrial membrane potential (p
