(‒)-Epicatechin modulates systemic and renal modifications in a rat model of endotoxemia

L. FISCHERMAN; C. G. FRAGA; M. GALLEANO; E. HID

Ferrara

Congreso; Society for Free Radical Research-Europe (SFRR-E) Annual Meeting; 2019

SFRR-E

Endotoxemia, characterized by systemic inflammation, is a major causeof acute kidney injury. In this work, Sprague-Dawley male rats, pretreatedfor 4 days with control diet or with diets supplemented with 20(low-level, LLE) or 80 (high-level, HLE) mg ()-epicatechin (EC)/kg ofbody weight/day, were challenged with bacterial lipopolysaccharide(LPS) (i.p. 4 mg/kg BW) and sacrificed 6 h post LPS administration. InLPS-treated endotoxemic animals, plasma GPT, GOT and LDH levels wereslightly or non-affected; nitric oxide (NO) levels in blood, measured byEPR, increased significantly, and HLE avoided 41% (p