BEHAVIORAL DISORDERS CAUSED BY ACUTE CARBON MONOXIDE POISONING AND ITS RELATIONSHIP WITH PROGNOSTIC BIOMARKERS

ROCÍO ALEJANDRA GALARZA; ANALIA G. KARADAYIAN; ANALÍA ELISABETH CORTEZ; MARÍA AGUSTINA MENEGHINI; SONIA MOLINA; ALICIA GRACIELA FALETTI

Hawaii

Congreso; IUTOX 15th International Congress of Toxicology; 2019

Society of Toxicology

Carbon monoxide poisoning (CO) is preventable and avoidable. Hundreds of people die by acute intoxication to CO and many of them suffer from the well-known ?late neurological syndrome? (LNS) with irreversible consequences. The aims of the present work were to assess the effects of an acute exposure to CO on the behavior, memory, anxiety and gait dynamics and to relate these changes to some prognostic biomarkers. To this end, adult rats were exposed to CO at acute doses (350 ppm for 20 seconds) capable of causing deterioration of the sensorium and different test were performed seven days post-intoxication. Compared with control animals (C), rats exposed to CO showed changes in the i) footprint test, compatible with ataxia, by exhibiting a greater maximum difference in the stride length, expressed as cm, (C: 6.50.9; CO: 9.10.7; P