IBIMOL   23987
INSTITUTO DE BIOQUIMICA Y MEDICINA MOLECULAR PROFESOR ALBERTO BOVERIS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
UNDERSTANDING THE MECHANISM OF SILVER NANOPARTICLE TOXICITY
Autor/es:
VALERIA CALABRO; MARÍA JIMENA SALGUEIRO; MARCELA A. MORETTON; VALACCHI GIUSEPPE; NATALIA MAGNANI; CACERES J; MARCELA ZUBILLAGA; SILVIA ALVAREZ; MARIANA GARCES; TIMOTEO MARCHINI; JUAN GALDOPORPORA; MARTIN DESIMONE; PABLO EVELSON
Lugar:
Buenos Aires
Reunión:
Jornada; XX Jornadas Anuales de la Sociedad Argentina de Biología y XVII Jornadas de la Sociedad Uruguaya de Biociencias 2018.; 2018
Resumen:
Along with the development of silver nanoparticles (AgNP) applications, the concern about their possible toxicity has increasingly gained attention. As the respiratory system in one of the main route of exposure, the aim of this study was to evaluate the harmful effects developed in lung after an acute AgNP exposure using 2D and 3D in vitro and in vivo models. When AgNP were characterized they showed a hydrodynamic diameter of 17±6 nm and they were able to initiate the hemolytic cleavage of H2O2 that may lead to OH? production. First, an in vitro approach was done in A549 cells exposed to 2.5 μg/mL AgNP up to 24h. A decreased in mitochondrial respiration (p