CHRONIC EXPOSURE TO URBAN AIR POLLUTION FROM BUENOS AIRES CITY ALTERS OXIDATIVE METABOLISM AND INFLAMMATION MARKERS IN MICE BRAIN CORTEX AND OLFACTORY BULB

CALABRÓ, VALERIA; BERDASCO, CLARA; SILVIA ÁLVAREZ; MARIANA GARCÉS; GOLDSTEIN, JORGE; MARCHINI, TIMOTEO; LOURDES CÁCERES; EVELSON, PABLO

Ciudad Autónoma de Buenos Aires

Congreso; XX Jornadas Anuales de la Sociedad Argentina de Biología (SAB) XVII Jornadas de la Sociedad Uruguaya de Biociencias (SUB). Segundas Jornadas Rioplatenses de Biología; 2018

Sociedad Argentina de Biología y Sociedad Uruguaya de Biociencias

Increasing evidence indicate that the central nervous system is a target of air pollution, causing alterations such as neuroinflammation and neurodegeneration. However, the mechanisms underlying these effects have not been fully elucidated. The aim of this work was to study the effects of chronic exposure to urban air pollution, on mice brain cortex (CX) and olfactory bulb (OB), focusing on oxidative and inflammatory parameters. C57BL/6J mice were continuously exposed to urban or filtered (control group) air from a central area of Buenos Aires city for 1, 2 or 4 weeks, housed in specially designed chambers. CX lipid oxidative damage, measured as TBARS, was increased after 1 week of urban air exposure compared to control mice (p