ROLE OF FENOFIBRATE ON THE IMMUNE RESPONSE IN AN EXPERIMENTAL MODEL OF CHAGAS DISEASE: MODULATION TO A REPARATIVE PROFILE IN THE HEART

RADA J; PENAS F; GOREN N; DONATO M; GELPI RJ; CEVEY A; MIRKIN G

Mar del Plata

Congreso; LXIII Reunión Científica Anual de la Sociedad Argentina de Investigación Clínica (SAIC).; 2018

Sociedad Argentina de Investigación Clínica

Chagas disease, the main cause of dilated cardiomyopathy in LatinAmerica, causes an inflammatory response that is critical for thecontrol of acute infection. Since benznidazole eliminates parasiteswhile PPARα ligands modulate inflammation and restores ventricularfunction, we evaluated the effect of fenofibrate (fen), a syntheticligand, on the modulation of the immune response in an experimentalmodel of T. cruzi (Tc) infection.BALB/c mice were sequentially infected with a non-lethal Tc strain.After 6 weeks (w) mice were reinfected with a lethal strain for additional4w. Thereafter, mice were treated with fen for 4w. Then, theexpression of several genes involved in the modulation of the immuneresponse to Tc infection was analyzed in the heart.IL-6, TNFα and NOS2 of Tc-infected mice (Tc), Tc-infected and treatedmice (Tc+fen) and uninfected mice were analyzed in the heartusing RTq-PCR. Infection increased the expression of IL-6, TNFαand NOS2 (p