OXIDATIVE DAMAGE OF BRAIN STRUCTURES IN A GLAUCOMA RAT MODEL AND THE PROTECTIVE ROLE OF LIPOIC ACID

FERREIRA, SANDRA; HVOZDA ARANA, AILEN GALA; BRUNZINI, RICARDO; PEVERINI, AGUSTINA; LASAGNI VITAR, ROMINA; LLESUY, SUSANA; REIDES, CLAUDIA; JANEZIC, NATASHA; LERNER, FABIAN

Paris

Congreso; Paris Redox 2017 - 19th International Conference on Antioxidants; 2017

International Society of Antioxidants

Introduction: Evidence of oxidative process was found in glaucoma brain3. The purpose was to evaluate the role of lipoic acid (LA) in oxidative damage of geniculate nucleus (GN) and visual cortex (VC) in glaucoma model. Material&Methods: Four groups of Wistar rats (n=20) were used: Glaucoma(G) rats were operated by cauterized two episcleral veins, glaucoma treated with LA100mg/kg(LG), Control(C) received sham procedure and Control treated with LA100mg/kg(LC). At seven days brains were removed. Thioredoxin reductase (TRxR), glutathione reductase (GR) and superoxide dismutase (SOD), protein oxidation (PO), lipid damage (TBARS) and glutathione (GSH) were evaluated.Results: Comparing LG to G: TRxR increased 52% in GN (7.6±0.4nmol/min.mgprotein p