IBIMOL   23987
INSTITUTO DE BIOQUIMICA Y MEDICINA MOLECULAR PROFESOR ALBERTO BOVERIS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Urban air pollution alters the redox balance of mice corneas
Autor/es:
JANEZIC N; MARTINEFSKI M; TRIPODI V; FERREIRA SM,; TESONE AI; TAU J; LASAGNI VITAR RM; REIDES CG; MARCHINI TO; BERRA A; HVOZDA ARANA AG; EVELSON PE; LLESUY S
Lugar:
Buenos Aires
Reunión:
Congreso; LXII Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC); 2017
Institución organizadora:
Sociedad Argentina de Investigación Clínica
Resumen:
Abstract: The exposure to air pollution leads to adverse health effects at levels that are currently experienced by urban population, in which oxidative stress is suggested to play a central role. The aim of the present study was to evaluate the redox balance in mice corneas after the exposure to urban air pollution. 8-week-old Balb/c male mice were exposed to urban air or filtered air (control) in an exposure chamber located in a highly populated area of Buenos Aires city. Air particulate matter levels in this area range between 20-60 μg/m3. The animals were exposed for 8 h/day, 5 days/week, up to 4 weeks. The local committee for animal care approved every experimental procedure. Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities, as well as protein oxidative damage were evaluated in corneal lysates. The animals exposed to urban air pollution showed an increase in SOD (115%) and CAT (218%) activities after a 1-week exposure (p