IBIMOL   23987
INSTITUTO DE BIOQUIMICA Y MEDICINA MOLECULAR PROFESOR ALBERTO BOVERIS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
TIME COURSE OF LUNG INFLAMMATION AND CARDIAC OXYGEN METABOLISM IN A MICE MODEL OF CONTINUOUS EXPOSURE TO URBAN AIR POLLUTION
Autor/es:
CALABRÓ VALERIA; CÁCERES LOURDES; VANASCO VIRGINIA; ALVAREZ SILVIA; MARCHINI TIMOTEO; GARCÉS MARIANA; PAZ MARIELA; LAGO NESTOR; VICO TAMARA; GUAGLIANONE ALEJANDRO; GONZALEZ MAGLIO DANIEL; BERRA ALEJANDRO; EVELSON PABLO
Lugar:
Ciudad Autónoma de Buenos Aires
Reunión:
Congreso; REUNIÓN CONJUNTA DE SOCIEDADES DE BIOCIENCIAS; 2017
Institución organizadora:
Sociedades Organizadoras: SAIC, SAIB, SAI, SAA, SAB, SAB, SAFE, SAFIS, SAH, SAP
Resumen:
The exposure to air pollution leads to increased morbidity and mortality rates from cardiorespiratory diseases. In has been suggested that local and systemic oxidative stress and inflammation play a central role in this scenario. The aim of this work was to characterize a mice model of continuous exposure to urban air pollution, by the assessment of different markers of pulmonary, systemic, and cardiac oxygen metabolism and inflammation. 8-week-old balb/c male mice were exposed to urban or filtered air (control) inside a chamber located in a highly populated area of Buenos Aires City. Animals were exposed for 8 h/day, 5 days/week, for up to 3 months. After 2 months, mice exposed to urban air pollution showed a 53% increase in total leucocytes in bronchoalveolar lavage (BAL) samples in comparison with the control group (control: 1.0±0.2 x105 cells, p