Evaluation of air pollution from buenos aires city effects on the mice geniculate nucleus.

JANEZIC NS; MARCHINI T; REIDES C,; FERREIRA SM,; LASAGNI VITAR R,; TAU J; EVELSON P; LLESUY S; TESONE A; HVOZDA ARANA A; BERRA A

Buenos Aires

Congreso; LXII Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC); 2017

Sociedad Argentina de Investigación Clínica

Abstract: The exposure to polluted air is an important cause to the development of adverse health effects in urban population. The aim of the present study was to evaluate oxidative stress markers on the geniculate nucleus on a mice model exposed to external ambiental air for 1, 2, and 4 weeks.8-week-old Balb/c male were exposed to urban air or filtered air (control) in an exposure chamber located in a highly populated area of Buenos Aires city. Air particulate matter levels in this area range between 20-60 µg/m3. The animals were exposed for 8h/day, 5days/week, up to 4 weeks. The local committee for animal care approved every experimental procedure. The following parameters were evaluated: The activity of Superoxide dismutase (SOD) and NADH Oxidase (NOX), lipid and protein oxidation (LO and PO, respectively). One-way ANOVA test and Dunnett?s test as post hoc test were used for statistical analysis.In the group of 1 week exposure, there was no significant difference between control and exposed groups in the parameters evaluated. We found a significant increase in the activity of SOD in the groups of 2 and 4 weeks exposure (47% and 19%, p