Effect of carvedilol or losartan on blood pressure variability and its impact on target organ damage in spontaneously hypertensive rats

BERTERA FM; GELPI RJ; CHIAPPETTA DA; PAROLA L; DEL MAURO JS; POLIZIO AH; SANTANDER PLANTAMURA YA; TAIRA CA; DONATO M; MORETTÓN M; HÖCHT C

Buenos Aires

Congreso; LXII Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC); 2017

The increase in blood pressure variability (BPV) has been established as an independent risk factor for the development of target organ damage in hypertensive patients. The aim was to evaluate the effects of the treatment of different antihypertensive agents on central arterial pressure, BPV and target organ damage in spontaneously hypertensive rats (SHR). Male SHR (200-250 g) received vehicle (n=6), carvedilol 15 mg/kg (n=6) or losartan 10 mg/kg (n=6)for 8 weeks. A fourth group of Wistar rats were used as normotensive control (n=6). At the end of the treatment, echocardiographic evaluation, direct and indirect blood pressure (BP) and short-term variability measurements were performed. Left ventricle was removed to assess ventricular hypertrophy.Chronic treatment with losartan, but not carvedilol, reduced indirect systolic BP. Both carvedilol and losartan diminished its intraday fluctuation compared to SHR. Also, both drugs significantly decreased carotid SBP and its short-term variability. Left ventricular mass was significantly reduced by chronic treatment with carvedilol (2.70±0.04 mg/g; P