IBIMOL   23987
INSTITUTO DE BIOQUIMICA Y MEDICINA MOLECULAR PROFESOR ALBERTO BOVERIS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
EXPOSITION TO INTERMITTENT HYPOXIA LEADS TO SUBMANDIBULAR GLAND ADAPTATION FAILURE
Autor/es:
MARIA PILAR MARTINEZ; ANTONELA TERRIZZI; TAMARA ZAOBORNYJ; TAMARA ZAOBORNYJ; JAVIER FERNANDEZ-SOLARI; MARÍA INÉS CONTI; JAVIER FERNANDEZ-SOLARI; MARÍA INÉS CONTI; MARIA PILAR MARTINEZ; ANTONELA TERRIZZI
Lugar:
Buenos Aires
Reunión:
Congreso; REUNIÓN CONJUNTA DE SOCIEDADES DE BIOCIENCIAS. SAIC- SAFE- etc; 2017
Institución organizadora:
SAIC
Resumen:
Hypobaric hypoxia (HX) is a stressful condition that induces activationof cellular components to maintain the physiology of several organs.If acclimation does not happen, deleterious effects occur. Theaim of this study was to establish the submandibular gland (SMG)function and bioenergetics in a model of rats exposed to chroniccontinuous hypoxia (CCH) or chronic intermittent hypoxia (CIH) inorder to elucidate whether these environmental conditions induceadaptive mechanisms in the organ. Methods: 45 adult female Wistarrats were divided into control (C), CIH (600 mbar, 18 hours fromMonday to Friday) and CCH (23,5 hours every day at the same presRESÚMENESDE LAS COMUNICACIONES 543sure). At day 75 pilocarpine-stimulated total salivary secretion ratewas measured. At day 90, animals were euthanized and SMG wereresected to perform mitochondrial characterization, assess oxidativestress and inflammatory markers and evaluate histopathologicalcharacteristics by optic and electronic microscopy. ANOVA wasused for statistics. Results: Salivary secretion decreased in animalsexposed to hypoxia, being lower in CIH (95% vs. 59% in CCH). Oxygenconsumption was higher in both hypoxic groups, but complexI activity was increased only in CCH. Mitochondrial hydrogen peroxideand superoxide dismutase activity remained unchanged, whetherthiobarbituric acid reactive species in the whole tissue increasedunder hypoxia (p