KIDNEY PROTECTION BY (-)-EPICATECHIN SUPPLEMENTATION IN HIGH FAT DIET FED MICE

FISCHERMAN L; FRAGA CG; OTEIZA PI; GALLEANO M

Mar del Plata

Congreso; LXI REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INVESTIGACIÓN CLÍNICA; 2016

Obesity is an independent risk factor for the developmentof cardiovascular disease, type 2 diabetes and other disorders.High amounts of saturated fats appears in part responsible forthe increased prevalence and incidence of obesity. Fruit andvegetable consumption has beneficial effects on health, thatcan be attributed to some particular compounds, based on theirchemical structure and population studies. This work aims toelucidate the effects of (?)-epicatechin (EC) on the mechanismsinvolved in insulin response and oxidative damage in kidney(cortex and medulla) of mice fed a high-fat diet (HFD). For 15 w,two experimental mice (C57BL/6) groups received control diet,with (CE) or without EC supplementation (C). Two other groupsreceived HFD (60% of calories from fat), with (EC) and without(EC) supplementation (HFE and HF, respectively). 10 minutesbefore animal euthanization, insulin was injected to half of theanimals of each group. Since the 6th week there was an increasedbody weight in HF respect to the other groups (p