(-)-Epicatechin Prevents Renal Modifications Induced by High-Fat Diet in Mice

GALLEANO M; TOBLLI JE; FRAGA CG; FISCHERMAN L; OTEIZA PI

San Francisco

Congreso; SfRBM 2016 & SFRRI 18th Biennial Meeting; 2016

Society for Redox Biology and Medicine

Fruit and vegetable consumption has beneficial effects on health that can be attributed to some particular compounds, based on their chemical structure and population studies. This work aims to elucidate the effects of (?)-epicatechin (EC) on the mechanisms involved in insulin response and oxidative damage in kidney (cortex and medulla) of mice fed a high-fat diet (HFD). For 15 w, two experimental mice (C57BL/6) groups received control diet, with (CE) or without EC supplementation (C). Two other groups received HFD (60% of calories from fat), with (EC) and without (EC) supplementation (HFE and HF, respectively). 10 minutes before animal euthanization, insulin was injected to half of the animals of each group. Since the 6th week there was an increased body weight in HF respect to the other groups (p