Protective role of lipoic acid in the oxidative damage of brain structures in a glaucoma rat model.

REIDES CG; JANEZIC, NS; FERREIRA SM; HVOZDA, A; LERNER F; PEVERINI, A; LASAGNI VITAR RM;; LLESUY SF

Congreso; LXI Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC); 2016

Evidence of oxidative process was found in glaucoma brain so the use of an antioxidant therapy may hold a promise for treatment. The purpose of this study was to evaluate the possible protective role of lipoic acid (LA) in the oxidative damage of geniculate nucleus (GN) and visual cortex (VC) in an experimental glaucoma model. Wistar rats (3 months) were divided in four groups (n=20): glaucoma in which rats were operated under a microscope by cauterized two of the episcleral veins (G), glaucoma treated with LA 100 mg/kg i.p. (LG), control which received a sham procedure (C) and control treated with lipoic acid 100 mg/kg i.p. (LC). Seven days after surgery rats were euthanized, brains were removed and GN and VC were separated. The following markers were evaluated: thioredoxin reductase (TRxR), glutathione reductase (GR) and superoxide dismutase (SOD) activities, protein oxidation (PO), damage to lipids (TBARS) and glutathione (GSH).Comparing LA treated glaucoma to glaucoma: TRxR increased 52% in GN (G:7.6±0.4 nmol/min.mg protein p