IBIMOL   23987
INSTITUTO DE BIOQUIMICA Y MEDICINA MOLECULAR PROFESOR ALBERTO BOVERIS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
COMPARISON OF REDOX STATUS IN LIVER AND BRAIN IN AN EXPERIMENTAL MODEL OF GLUTAMATE MEDIATED EXCITOTOXICITY
Autor/es:
LAIRION FN.; REIDES CG,; FERREIRA SANDRA; CALABRO VALERIA ; LLESUY SUSANA ; HVOZDA ARANA A; WEICHSLER N,
Reunión:
Congreso; LXI Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC); 2016
Resumen:
Increased levels of glutamate, main excitatory neurotransmitter in the central nervous system, have been associated with various neurological disorders, such as epilepsy, cerebral ischemia,Parkinson and glaucoma. The aim of this study was to assess changes in the redox status in the liver and the brain of rats subject to glutamate mediated excitotoxicity.The experimental model consisted of one group (n=3) injected ip with 1g glutamate/kg weight (GHD), another group (n=3) injected ip with 0.5 g glutamate/kg weight (GLD) and control group (n=3) injected ip with saline solution (CG). All groups received glutamate or saline solution at days 1, 5 and 9. The following markers were evaluated in liver and in brain homogenates: lipid oxidation (TBARS), catalase (CAT) levels, and the activities of superoxide dismutase (SOD) and glutathione transferase (GT). The results in brain showed that both doses of glutamate produced a significant increase of SOD (31% GLD p