Glaucoma induces changes in the antioxidant status of brain visual structures.

FERREIRA SM, ; LERNER SF,; LASAGNI VITAR RM,; REIDES CG, ; LLESUY SF

CABA

Congreso; VIII Meeting of the SFRBM; 2013

South American Group

Purpose: To establish if the brain is a target of oxidative damage in a glaucoma model. Methods: Ocular hypertension was induced in Wistar rats (n=12). A sham procedure (n=12) was performed in control. The markers evaluated in brain visual structures at seven days were: thioredoxin reductase (TR), glutathione peroxidase (GPX), superoxide dismutase (SOD), glutathione reductase (GR), glucose-6-phosphate dehydrogenase (G6PD), NADPH oxidase (NAOX), spontaneous chemiluminescence (CL), carbonyl groups (PC), nitrite concentration (NC), glutathione (GSH), ascorbic acid (AA), and vitamin E (VE). Results: TR was 0.19±0.04nmol/min.mg (control 0.42±0.03nmol/min.mg p