Chronic exposure to urban air pollution in Buenos Aires city induces oxidative stress, inflammation and olfactory alteration over time in mice olfactory bulb

SOFÍA REYNOSO; TIMOTEO MARCHINI; VALERIA TRIPODI; SILVIA ALVAREZ; AGUSTINA FREIRE; LOURDES CÁCERES; NAHUEL MENDEZ DIODATI; JORGE GOLDSTEIN; NATALIA MAGNANI; MARIANA GARCÉS; OCTAVIO DIANA; MANUELA MARTINEFSKI; BRUNO BUCHHOLZ; PABLO EVELSON

Viena

Congreso; Redox Biology in translation annual meeting of the society for free radical research-Europe; 2023

Previous reports indicate that the brain is a target of air pollution, causing tissue damage and functional alterations. The aim of this work was to study the chronic effects of urban air pollution on olfactory bulb (OB), focusing on oxidative stress and inflammation as possible mechanisms mediating these effects. BALB/c 8-week-old mice were exposed to filtered air (FA, control) or urban air (UA) inside whole-body chambers, located in a highly polluted area of Bs. As. city, for up to 4w. Regarding OB redox status, UA exposed mice showed a decreased reduced glutathione level (p