Biomarkers of oxidative stress and inflammation associated with differential diagnoses in ageing patients with Leukoaraiosis and Alzheimer disease.

MARGARITA MARTÍNEZ SARRASAGUE; JORGE SERRA; GRACIELA ADA BIANCHI; FABIANA LAIRION; ENRIQUE MARSCHOFF; RAÚL DOMINGUEZ; ALEJANDRA CIMATO; CHRISTIAN SAPORITO; LILIANA OUDERK; MARISA GABRIELA REPETTO

CIUDAD AUTONOMA BUENOS AIRES

Congreso; Reunion Anual de Sociedades de Biociencia. SAIC, SAI, AAFE, NANOMED-ar.; 2021

SAIC

Previous results indicate that oxidative stress (OS) and damage (OD) are associated to the etiopathogenesis of neurodegenerative disorders. Leukoaraiosis (L) is related to the small cerebral vessel disease and mainly associated with aging, dementia, hypertension, cognitive impairment and Alzheimer disease (AD). The aim of this research is to evaluate whether OS and OD are associated with inflammatory response in L and AD patients. Biomarkers of OS, OD and inflammation were evaluated in 33 ageing patients: 17 with diagnosis of L (magnetic resonance imaging and brain computed tomography) and 16 with AD (neurological and cognitive tests), and healthy subjects (controls, n=17). The following parameters were assessed in plasma: protein oxidation measured as carbonyl groups (CO), phospholipid oxidation, measured as the content of thiobarbituric acid reactive substances (TBARS), interleukin 6 (IL-6), total antioxidant (TRAP) and protein content; and in red cells: protein content, superoxide dismutase and catalase activities. A 100% increase of TBARS was observed in L (p